Protein fold recognition using sequence-derived predictions
نویسندگان
چکیده
منابع مشابه
Hybrid Fold Recognition : Combining Sequence Derived
Recent assessments of structure prediction have demonstrated that (i) although fold recognition methods can often identify remote similarities when standard sequence search methods fail, the score of the top-ranking fold is not always signii-cant enough to allow a conndent prediction; (ii) the use of structural information such as secondary structure increases recognition accuracy; (iii) modern...
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A protein local substructure (descriptor) is a set of several short non-overlapping fragments of the polypeptide chain. Each substructure describes local environment of a particular residue and includes only those segments of the main chain that are located in the proximity of that residue. Similar descriptors from the representative set of proteins were analyzed to reveal links between the sub...
متن کاملHybrid fold recognition: combining sequence derived properties with evolutionary information.
Recent assessments of structure prediction have demonstrated that (i) although fold recognition methods can often identify remote similarities when standard sequence search methods fail, the score of the top-ranking fold is not always significant enough to allow a confident prediction; (ii) the use of structural information such as secondary structure increases recognition accuracy; (iii) moder...
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We present an overview of the fifth round of Critical Assessment of Protein Structure Prediction (CASP5) fold recognition category. Prediction models were evaluated by using six different structural measures and four different alignment measures, and these scores were compared to those assigned manually over a diverse subset of target domains. Scores were combined to compare overall performance...
متن کاملProtein Fold Recognition Using Gradient Boost Algorithm
Protein structure prediction is one of the most important and difficult problems in computational molecular biology. Protein threading represents one of the most promising techniques for this problem. One of the critical steps in protein threading, called fold recognition, is to choose the best-fit template for the query protein with the structure to be predicted. The standard method for templa...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1996
ISSN: 0961-8368
DOI: 10.1002/pro.5560050516